Recombinant Human RSPO3 Protein (Fc & His Tag)

Product Specifications

Background

R-spondin-3 (RSPO3) ; also known as Protein with TSP type-1 repeat; Roof plate-specific spondin-3; Thrombospondin type-1 domain-containing protein 2; PWTSR; THSD2 and CRISTIN1; is a member of the thrombospondin type 1 repeat supergene family. RSPO3 is a secreted protein and widely expressed in many tissues. RSPO3 contains two Furin-like repeats which have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases; and one TSP type-1 domain; RSPO3 founctions as a activator of the beta-catenin signaling cascade; leading to TCF-dependent gene activation. Otherwise; RSPO3 may negatively regulate the TGF-beta pathway.

Abbreviation

RSPO3

Synonyms

CRISTIN1; PWTSR; Protein with TSP type-1 repeat; R-spondin-3; RSPO3; Roof plate-specific spondin-3; THSD2; Thrombospondin type-1 domain-containing protein 2

UniProt

Q9BXY4

Accession Number

Q9BXY4

Expression System

HEK293 Cells

Tag

C-Fc-His

Sequence

Gln22-Val201

Field of Research

Stem Cells, Developmental Biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.