Recombinant Human Chymotrypsin C Protein (His Tag)
Product Specifications
Background
Chymotrypsin C (CTRC) is a member of the peptidase S1 family. CTRC is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. CTRC has broad substrate specificity; but prefers tocleave on the carboxyl side of hydrophobic residues. CTRC is expressed primarily in the pancreas; and is secreted into the digestive tract. CTRC plays a protective role in the pancreas by mitigating premature trypsinogen activation through degradation. It has been proposed that CTRC is a key regulator of digestive zymogen activation and is a physiological coactivator of digestive carboxypeptidases proCPA1 and proCPA2. The mutation of CTRC gene encodes the digestive enzyme CTRC contribute to the development of pancreatitis.
Abbreviation
Chymotrypsin C
Synonyms
CLCR; CTRC; Caldecrin; Chymotrypsin-C
UniProt
Q99895
Accession Number
Q99895
Expression System
HEK293 Cells
Tag
C-His
Sequence
Cys17-Leu268
Field of Research
Cell biology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
29.0 kDa
Observed Molecular Weight
33-40 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-Hcl, 150mM NaCl , pH7.5.
Species
Human
Available Sizes
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