Recombinant Human ST6GAL1 Protein (His Tag)
Product Specifications
Background
The ST6GAL1 gene encodes β-Galactosamide α-2;6-Sialyltransferase 1. It is a type II membrane protein and is localized to the trans-Golgi network. It catalyzes 2;6-sialylation of Galβ1;4-GlcNAc structures on N-glycans. ST6GAL1 is highly expressed in the liver and other tissues. ST6GAL1 deficiency causes abnormalities in B-cell immunoreactivity. The expression and activity of ST6GAL1 are associated with tumor metastasis in breast and colon cancers. The majority of ST6GAL1 in the liver is cleaved and secreted into the serum and may be used as a biomarker for hepatitis diseases.
Abbreviation
ST6GAL1
Synonyms
6-ST 1;6-Sialyltransferase 1; Alpha 2; B-Cell Antigen CD75; Beta-Galactoside Alpha-2; CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2; SIAT1; ST6GAL1; ST6Gal I; ST6GalI; Sialyltransferase 1
UniProt
P15907
Accession Number
P15907
Expression System
HEK293 Cells
Tag
C-His
Sequence
Lys27-Cys406
Field of Research
Signal Transduction; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
44.6 kDa
Observed Molecular Weight
41-60 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Species
Human
Available Sizes
Documents
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