Recombinant Human SULT1A1 Protein (His Tag)
Product Specifications
Background
Sulfotransferase 1A1 (SULT1A1) is a cytosolic sulfotransferases that is expressed in the liver; lung; adrenal; brain; platelets; and skin. SULT1A1 is a phenol sulfotransferases with thermostable enzyme activity. SULT1A1 utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines; phenolic drugs and neurotransmitters. It is responsible for the sulfonation and activation of minoxidil. SULT1A1 mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
Abbreviation
SULT1A1
Synonyms
Aryl sulfotransferase 1; HAST1/HAST2; OK/SW-cl.88; P-PST 1; Phenol Sulfotransferase 1; Phenol-Sulfating Phenol Sulfotransferase 1; ST1A1; ST1A3; STP; STP1; SULT1A1; Sulfotransferase 1A1; Thermostable Phenol Sulfotransferase; Ts-PST
UniProt
P50225
Accession Number
AAH00923.1
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Leu295
Field of Research
Signal Transduction, Cancer, Metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
35.6 kDa
Observed Molecular Weight
32 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM PB, 10% Trehalose, 50mM Nacl, 0.05% Tween 80, pH7.8.
Species
Human
Available Sizes
Documents
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