Recombinant Human C1QBP Protein (aa 74-282, His Tag)
Product Specifications
Background
Complement Component 1Q Subcomponent-Binding Protein (C1QBP) is a nucleus protein that belongs to the MAM33 family. C1QBP is known to bind to the globular heads of C1q molecules and inhibit C1 activation. Mitochondrial C1QBP is a critical mediator of p14ARF-induced apoptosis. C1QBP functions as a chemotactic factor for immature dendritic cells, and migration is mediated through ligation of both C1QBP and cC1qR/CR. C1QBP overexpression successfully blocks mRNA accumulation from the adenovirus major late transcription unit (MLTU) and stimulates RNA polymerase II carboxy-terminal domain phosphorylation in virus-infected cells.
Abbreviation
C1QBP
Synonyms
ASF/SF2-Associated Protein p32; C1QBP; C1qBP; Complement Component 1 Q Subcomponent-Binding Protein Mitochondrial; GC1QBP; Glycoprotein gC1qBP; HABP1; Hyaluronan-Binding Protein 1; Mitochondrial Matrix Protein p32; SF2P32; gC1q-R Protein; gC1qR; p33
Accession Number
Q07021
Expression System
E.coli
Tag
C-His
Sequence
Leu74-Gln282
Field of Research
Microbiology; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
24.9 kDa
Observed Molecular Weight
34 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 20% Glycerol, 1mM DTT, pH 7.5.
Species
Human
Available Sizes
Documents
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