Recombinant Human CLIC4 Protein (His Tag)
Product Specifications
Background
Chloride Intracellular Channel Protein 4 (CLIC4) is a 253 amino acid single-pass membrane protein that localizes to both the nucleus and the cytoplasm and contains one GST C-terminal domain. CLIC4 is expressed in various tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells) . CLIC4 acts as a monomer which is able to form selective ion channels in target proteins; thus facilitating the transport of chloride and other ions. CLIC4 is believed to have a role in apoptosis and is able to translocate to the nucleus under stress conditions. CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis.
Abbreviation
CLIC4
Synonyms
CLIC4L; H1; MTCLIC; huH1; p64H1
UniProt
Q9Y696
Accession Number
Q9Y696
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Lys253
Field of Research
Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction, Metabolism, Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
30.9 kDa
Observed Molecular Weight
32 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, pH 8.0.
Species
Human
Available Sizes
Curated Selection
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