Recombinant Human Ube2H Protein (GST Tag)

Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes; or E1s; ubiquitin-conjugating enzymes; or E2s; and ubiquitin-protein ligases; or E3s. It has been shown to conjugate ubiquitin to histone H2A in an E3 dependent manner in vitro. UBE2H is the human homolog to the yeast DNA repair gene RAD6; which is induced by DNA damaging reagents. UBE2H has been associated with cancer-induced cachexia and with the regulation of sepsis-induced muscle proteolysis.

E2-20K; GID3; UBC8; UBCH; UBCH2; UBE2H; UbcH2; Ubiquitin Carrier Protein H; Ubiquitin-Conjugating Enzyme E2 H; Ubiquitin-Conjugating Enzyme E2-20K; Ubiquitin-Protein Ligase H