Recombinant Human IL1RL1/ST2 Protein (His Tag)

Product Specifications

Background

Interleukin 1 receptor-like 1 (IL1RL1) is a member of the interleukin-1 receptor family, Contains 3 Ig-like C2-type domains and 1 TIR domain. It is highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. IL1RL1 is a receptor for interleukin-33, its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 may possibly be involved in helper T-cell function. Soluble IL1RL1 also acts as a negative regulator of Th2 cytokine production, it directly implicated in the progression of cardiac disease.

Abbreviation

IL1RL1; ST2

Synonyms

FIT; DER; IL1RL; IL-1 R; IL1RL1; DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1; IL-1 R4; DER-4; FIT 1; Growth stimulation expressed; Growth stimulation expressed gene 2; homolog of mouse growth stimulation-expressed; IL-1R4; ILRL1; Interleukin 1 receptor like 1; interleukin 1 receptor related protein; Interleukin-1 receptor-like 1; Protein ST2; T1 protein

UniProt

Q01638

Accession Number

Q01638-2

Expression System

HEK293 Cells

Tag

C-His

Sequence

Lys19-Phe328

Field of Research

Cardiovascular, Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.