Recombinant Human CDCP1/CD318 Protein (aa 30-341, His Tag)
Product Specifications
Background
CUB domain-containing protein 1 (CDCP1) is a transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains; and a smaller intracellular domain (ICD) containing five tyrosines. CDCP1 is widely expressed in human epithelial tissues; but its phosphorylation is only seen in mitotically detached or shedding cells; consistent with its role in the negative regulation of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsinor EDTA; or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype.
Abbreviation
CDCP1; CD318
Synonyms
CD318; CUB domain-containing protein 1; Membrane glycoprotein gp140; SIMA135; Subtractive immunization M plus HEp3-associated 135 kDa protein; TRASK; Transmembrane and associated with src kinases
UniProt
Q9H5V8
Accession Number
Q9H5V8-3
Expression System
HEK293 Cells
Tag
C-His
Sequence
Phe30-Ser341
Field of Research
Tags & Cell Markers, Stem Cells, Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 85 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/xqm9xd
Product MSDS
https://789.bio/eb/D8K4iP
Calculated Molecular Weight
36.1 kDa
Observed Molecular Weight
55 kDa
Species
Human
Available Sizes
Curated Selection
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