Recombinant Human SMPDL3A Protein (His Tag)
Product Specifications
Background
Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A) is a novel liver X receptor (LXR) -regulated gene; with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR function as physiological sensors of cholesterol metabolites (oxysterols) ; regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems; revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases.
Abbreviation
SMPDL3A
Synonyms
ASM-Like Phosphodiesterase 3a; ASML3A; Acid Sphingomyelinase-Like Phosphodiesterase 3a; SMPDL3A
UniProt
Q92484
Accession Number
Q92484
Expression System
HEK293 Cells
Tag
C-His
Sequence
Leu23-Tyr453
Field of Research
Signal Transduction; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/wq5cx9
Product MSDS
https://789.bio/eb/GC8eLC
Calculated Molecular Weight
49.9 kDa
Observed Molecular Weight
59 kDa
Species
Human
Available Sizes
Curated Selection
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