Recombinant Human ECH1 Protein
Product Specifications
Background
Human delta (3,5) -Delta (2,4) -dienoyl-CoA isomerase (ECH1) is a member of the hydratase/isomerase superfamily and contains a C-terminal peroxisomal targeting sequence and localizes to peroxisomes. ECH1 shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. The rat orthologlocalizes to the matrix of both the peroxisome and mitochondria.It can isomerize 3-trans, 5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. ECH1 plays an important role in the auxiliary step of the fatty acid beta-oxidation pathway.
Abbreviation
ECH1
Synonyms
4) -dienoyl-CoA isomerase;5) -Delta (2; Delta (3; ECH1; mitochondrial
UniProt
Q13011
Accession Number
Q13011
Expression System
E.coli
Tag
N-His
Sequence
Thr34-Leu328
Field of Research
Signal Transduction; Tags & Cell Markers; Cardiovascular; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
34.5 kDa
Observed Molecular Weight
30-35 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 5mM EDTA, pH 8.0.
Species
Human
Available Sizes
Documents
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