Recombinant Human VCP Protein (His Tag)
Product Specifications
Background
Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. VCP participates in the formation of the transitional endoplasmic reticulum (tER) and regulates E3 ubiquitin-protein ligase activity of RNF19A.
Abbreviation
VCP
Synonyms
15S Mg (2+) -ATPase p97 Subunit; TER ATPase; Transitional Endoplasmic Reticulum ATPase; VCP; Valosin-Containing Protein
UniProt
P55072
Accession Number
P55072
Expression System
E.coli
Tag
C-His
Sequence
Ala2-Asn589
Field of Research
Signal Transduction; Neuroscience; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
66.3 kDa
Observed Molecular Weight
75 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, pH8.0.
Species
Human
Available Sizes
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