Recombinant Human UBE2V2/DDVIT1 Protein (His Tag)
Product Specifications
Background
Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains and which leads to protein degradation by the proteasome. UBE2V2 mediates transcriptional activation of target genes. It plays a role in the control of progress through the cell cycle and differentiation. It also plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Abbreviation
UBE2V2; DDVIT1
Synonyms
DDVit 1; EDAF-1; EDPF-1; Enterocyte Differentiation-Associated Factor 1; Enterocyte Differentiation-Promoting Factor 1; MMS2; MMS2 Homolog; UBE2V2; UEV2; Ubiquitin-Conjugating Enzyme E2 Variant 2; Vitamin D3-Inducible Protein
UniProt
Q15819
Accession Number
Q15819
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Asn145
Field of Research
Cell biology; epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
18.5 kDa
Observed Molecular Weight
18 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 50mm HEPES,150mM NaCl, pH 7.0.
Species
Human
Available Sizes
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