Recombinant Human UBE2S Protein (GST Tag)
Product Specifications
Background
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activating Enzyme-Dependent manner, a characteristic property of Ubiquitin Carrier Proteins. UBE2S acts as an essential factor of the Anaphase Promoting Complex/Cyclosome, a cell cycle-regulated Ubiquitin ligase that controls progression through mitosis. UBE2S is also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A.
Abbreviation
UBE2S
Synonyms
E2-EPF; E2EPF; UBE2S; Ubiquitin Carrier Protein S; Ubiquitin-Conjugating Enzyme E2 S; Ubiquitin-Conjugating Enzyme E2-24 kDa; Ubiquitin-Conjugating Enzyme E2-EPF5; Ubiquitin-Protein Ligase S
UniProt
Q16763
Accession Number
Q16763
Expression System
E.coli
Tag
N-GST
Sequence
Met 1-Leu222
Field of Research
Epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
50.1 kDa
Observed Molecular Weight
50 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5.
Species
Human
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GP-2002-20 1 mL
Colloidal Gold Conjugated Ricinus communis Lectin (Castor Bean) -RCA-II-, 20nm
Sign In for Pricing
View Details 
![Histone H3 Mouse Monoclonal Antibody [3-C4]](https://cdn.genprice.uk/products/992/68dd1c8b061270361ea8177c/imageurl/em30605.webp)
![MRTFA Mouse Monoclonal Antibody [Clone ID: OTI3G7]](https://cdn.genprice.uk/products/937/68dd18b9061270361e907cb7/imageurl/cf805226.webp)
