Recombinant Human HIP2/UBE2K Protein (GST Tag)
Product Specifications
Background
Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain; with highest levels found in cortex and striatum; and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins; such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition; UBE2K is involved in Alzheimer's disease; Huntington's disease and antigen processing through its interaction with huntingtin; and MHC-heavy chain proteins.
Abbreviation
HIP2; UBE2K
Synonyms
HIP-2; HIP2; Huntingtin-Interacting Protein 2; LIG; UBE2K; Ubiquitin Carrier Protein; Ubiquitin-Conjugating Enzyme E2 K; Ubiquitin-Conjugating Enzyme E2 (25K) ; Ubiquitin-Conjugating Enzyme E2-25 kDa; Ubiquitin-Conjugating Enzyme E2-25K; Ubiquitin-Protein Ligase
UniProt
P61086
Accession Number
P61086
Expression System
E.coli
Tag
N-GST
Sequence
Met 1-Asn200
Field of Research
Cell biology; Neuroscience; epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
48.7 kDa
Observed Molecular Weight
45 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5.
Species
Human
Available Sizes
Curated Selection
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