Recombinant Human HIP2/UBE2K Protein (His Tag, SUMO Tag)

Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain; with highest levels found in cortex and striatum; and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins; such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition; UBE2K is involved in Alzheimer's disease; Huntington's disease and antigen processing through its interaction with huntingtin; and MHC-heavy chain proteins.

HIP-2; HIP2; Huntingtin-Interacting Protein 2; LIG; UBE2K; Ubiquitin Carrier Protein; Ubiquitin-Conjugating Enzyme E2 K; Ubiquitin-Conjugating Enzyme E2 (25K) ; Ubiquitin-Conjugating Enzyme E2-25 kDa; Ubiquitin-Conjugating Enzyme E2-25K; Ubiquitin-Protein Ligase