Recombinant Human UBE2B/HR6B Protein (His Tag)
Product Specifications
Background
Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2B interacts with RAD18; UBR2; and WAC. UBE2B is required for post-replicative DNA damage repair. Additional; UBE2B plays a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia.
Abbreviation
UBE2B; HR6B
Synonyms
HR6B; RAD6 Homolog B; RAD6B; UBE2B; Ubiquitin Carrier Protein B; Ubiquitin-Conjugating Enzyme E2 B; Ubiquitin-Conjugating Enzyme E2-17 kDa; Ubiquitin-Protein Ligase B; hHR6B
UniProt
P63146
Accession Number
P63146
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met 1-Ser152
Field of Research
Cell biology; Cancer; epigenetics and nuclear signal; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
18.3 kDa
Observed Molecular Weight
17 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Species
Human
Available Sizes
Documents
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