Recombinant Human UCHL1/PGP9.5 Protein (His Tag)
Product Specifications
Background
Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 (UCHL1) belongs to the Peptidase C12 family. UCHL1 is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. UCHL1 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. UCHL1 is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity.
Abbreviation
UCHL1; PGP9.5
Synonyms
HEL-117; NDGOA; Neuron Cytoplasmic Protein 9.5; PARK5; PGP 9.5; PGP9.5; UCH-L1; UCHL1; Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1; Ubiquitin Thioesterase L1; Uch-L1
UniProt
P09936
Accession Number
P09936
Expression System
E.coli
Tag
C-His
Sequence
Met 1-Ala223
Field of Research
Tags & Cell Markers; Cell biology; Neuroscience
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
25.9 kDa
Observed Molecular Weight
26 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 250mM NaCl, 1mM DTT, 10% Glycerol, pH 7.5.
Species
Human
Available Sizes
Documents
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