Recombinant Human Tie1 Protein (His Tag)
Product Specifications
Background
TIE-1 (Tyrosine Kinase with Ig and EGF Homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily. These receptors are expressed on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18aa signal peptide, a 727 aa extracellular domain and a 354 aa cytoplasmic domain. so far, two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) ], but no ligand was found for TIE-1.
Abbreviation
Tie1
Synonyms
TIE; TIE1; Tyrosine-Protein Kinase Receptor Tie-1
UniProt
P35590
Accession Number
P35590
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ala22-Gln760
Field of Research
Signal Transduction; Cardiovascular; Cancer; Developmental Biology; Stem cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/pqay90
Product MSDS
https://789.bio/eb/CGeTK4
Calculated Molecular Weight
81.0 kDa
Observed Molecular Weight
87 kDa
Species
Human
Available Sizes
Curated Selection
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