Recombinant Human TNFRSF1B/CD120b Protein (aa 288-461, His Tag)

Product Specifications

Background

Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is expressed by the gene TNFRSF1B. The soluble form is produced from the membrane form by proteolytic processing. It can bind to TRAF2; and interacts with BMX. It can act as the receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha.

Abbreviation

TNFRSF1B; CD120b

Synonyms

TNF-R2; TNF-RII; TNFR-II; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor

UniProt

P20333

Accession Number

P20333

Expression System

HEK293 Cells

Tag

C-His

Sequence

Lys288-Ser461

Field of Research

Signal Transduction; Cell biology; Cardiovascular; Neuroscience; Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.