Recombinant Human TCblR/8D6A Protein (Fc Tag)

Product Specifications

Background

CD320 antigen is also known as 8D6 antigen, FDC-signaling molecule 8D6, Transcobalamin receptor and 8D6A. It is a single-pass type I membrane protein and containing two LDL-receptor class A domains. CD320 has been recently discovered and reported as a follicular dendritic cell (FDC) protein. CD320 can augments the proliferation of plasma cells precursors generated by IL-10. CD320 also founctions a receptor for the cellular uptake of transcobalamin bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC) which is a metabolic disorder.

Abbreviation

TCblR;8D6A

Synonyms

8D6 antigen; CD320; CD320 antigen; FDC-SM-8D6; FDC-signaling molecule 8D6; TCblR; Transcobalamin receptor

UniProt

Q9NPF0

Accession Number

Q9NPF0

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Ser36-Val231

Field of Research

Cell biology; Developmental Biology; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.