Recombinant Human TRAIL R3/TNFRSF10C Protein (His Tag)
Product Specifications
Background
Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains; lacks the intracellular signaling domain. As a result; binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
Abbreviation
TRAIL R3; TNFRSF10C
Synonyms
Antagonist Decoy Receptor for TRAIL/Apo-2L; DcR1; Decoy Receptor 1; Decoy TRAIL Receptor Without Death Domain; Lymphocyte Inhibitor of TRAIL; TNF-Related Apoptosis-Inducing Ligand Receptor 3; TRAIL Receptor ; Tumor Necrosis Factor Receptor Superfamily Member 10C
UniProt
O14798
Accession Number
O14798
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ala26-Ala221
Field of Research
Cell biology; Cancer; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/9hmpd9
Product MSDS
https://789.bio/eb/D0yvLO
Calculated Molecular Weight
21.8 kDa
Observed Molecular Weight
38-58 kDa
Species
Human
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
