Recombinant Human THOP1 Protein (His Tag)
Product Specifications
Background
Thimet Oligopeptidase (THOP1) belongs to the peptidase M3 family which includes neurolysin and mitochondrial intermediate peptidase. THOP1 is located in Cytoplasm. THOP1 is widely expressed in human tissues and can detected in different subcellular locations. THOP1 is preferential cleavage for bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues. THOP1 is involved in the metabolism of neuropeptides under 20 amino acid residues and degradation of cytoplasmic peptide. In addition, THOP1 also can degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
Abbreviation
THOP1
Synonyms
Endopeptidase 24.15; MP78; THOP1; Thimet Oligopeptidase
UniProt
P52888
Accession Number
P52888
Expression System
E.coli
Tag
C-His
Sequence
Lys2-Cys689
Field of Research
Neuroscience
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
80.0 kDa
Observed Molecular Weight
85 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 50% Glycerol, pH 7.4.
Species
Human
Available Sizes
Documents
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