Recombinant Human SOD2/Mn-SOD Protein (His Tag)
Product Specifications
Background
Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6) ; idiopathic cardiomyopathy (IDC) ; sporadic motor neuron disease; and cancer. SOD2 destroys superoxide anion radicals which are usually produced within the cells and which are toxic to biological systems.
Abbreviation
SOD2; Mn-SOD
Synonyms
SOD2; Superoxide Dismutase [Mn] Mitochondrial
UniProt
P04179
Accession Number
P04179
Expression System
E.coli
Tag
N-His
Sequence
Lys25-Lys222
Field of Research
Signal Transduction; Cell biology; Cardiovascular; Neuroscience; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
23.7 kDa
Observed Molecular Weight
25 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 50% Glycerol, pH 8.0.
Species
Human
Available Sizes
Documents
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