Recombinant Human STAT3 Protein (His Tag)
Product Specifications
Background
Signal Transducer and Activator of Transcription 3 (STAT3) belongs to the transcription factor STAT family. STAT3 contains one SH2 domain and is a transcription factor expressed in most cell types. STAT3 is activated by multiple cytokines and growth factors including: IFN-a, IL-10, IL-6, IL-11, IL-12, IL-2, EGF etc. STAT3 functions as signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. In addition, STAT3 may also mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Abbreviation
STAT3
Synonyms
APRF; Acute-Phase Response Factor; STAT3; Signal Transducer and Activator of Transcription 3
UniProt
P40763
Accession Number
P40763
Expression System
E.coli
Tag
C-His
Sequence
Met 1-Asn175
Field of Research
Signal Transduction; Cardiovascular; Cancer; Developmental Biology; epigenetics and nuclear signal; Stem cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
21.8 kDa
Observed Molecular Weight
19&46 kDa
Species
Human
Available Sizes
Documents
Frequently Asked Questions
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