Recombinant Human SerpinB3/SCCA1 Protein (E.coli, His Tag)

Product Specifications

Background

Serpin B3, also known as squamous cell carcinoma antigen-1 (SCCA-1), is a member of the serpin superfamily of serine protease inhibitors. Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in the regulation of apoptosis, inflammation, angiogenesis and embryogenesis. It may act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. It also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH (2) -terminal kinase (JNK1) .

Abbreviation

SerpinB3; SCCA1

Synonyms

HsT1196; Protein T4-A; SCC; SCCA-1; SCCA1; Serpin B3; Squamous cell carcinoma antigen 1; T4-A; clade B (ovalbumin) ; member 3; serine (or cysteine) proteinase inhibitor; serpin peptidase inhibitor

UniProt

P29508

Accession Number

P29508

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Pro390

Field of Research

Cell biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.