Recombinant Human SENP7 Protein
Product Specifications
Background
Sentrin-Specific Protease 7 (SENP7) acts as a SUMO-2/3-specific protease. SENP7 is likely to regulate the metabolism of poly-SUMO-2/3 rather than SUMO-1 conjugation in vivo. SENP7 has a restricted substrate specificity, and displaying paralogue-specific isopeptidase activity. The C-terminal catalytic domain of SENP7 depolymerized poly-SUMO-2 chains but does not have activity against poly-SUMO-1 chains. SENP7 also had isopeptidase activity against di-SUMO-2- and SUMO-2-modified RanGAP1 (Ran GTPase-activating protein 1) but had limited activity against SUMO-1-modified RanGAP1.
Abbreviation
SENP7
Synonyms
KIAA1707; SENP7; SSP2; SUMO-1-Specific Protease 2; SUSP2; Sentrin-Specific Protease 7; Sentrin/SUMO-Specific Protease SENP7
UniProt
Q9BQF6
Accession Number
Q9BQF6
Expression System
E.coli
Tag
None
Sequence
Met695-Ala864
Field of Research
Cell biology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
19.8 kDa
Observed Molecular Weight
22 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM HEPES, 5% Glycerol, pH 7.4.
Species
Human
Available Sizes
Documents
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