Recombinant Human SENP2 Protein
Product Specifications
Background
SENP2 is an enzyme that belongs to the peptidase C48 family. SENP2 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SUMO1 is a small ubiquitin-like protein that can be covalently conjugated to other proteins. It has been implicated as a down-regulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway.
Abbreviation
SENP2
Synonyms
Axam2; KIAA1331; SENP2. ; SMT3-specific isopeptidase 2; Sentrin-specific protease 2; Sentrin/SUMO-specific protease SENP2
UniProt
Q9HC62
Accession Number
Q9HC62
Expression System
E.coli
Tag
None
Sequence
Asp363-Leu589
Field of Research
Cell biology; epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
26.8 kDa
Observed Molecular Weight
29 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 50mM HEPES,5% Glycerol, pH 7.4.
Species
Human
Available Sizes
Documents
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