Recombinant Human RANK/TNFRSF11A Protein (His Tag)

Product Specifications

Background

Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas.

Abbreviation

RANK; TNFRSF11A

Synonyms

CD265; CD265 antigen; FEO; ODFR; ODFROSTS; OFE; OPTB7; PDB2; RANK1; Receptor activator of NF-KB; TNFRSF11A; TRANCE R; TRANCER; receptor activator of nuclear factor-kappa B; tumor necrosis factor receptor superfamily member 11A

UniProt

Q9Y6Q6

Accession Number

Q9Y6Q6

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ile30-Pro212

Field of Research

Signal Transduction; Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.