Recombinant Human Proteoglycan 3/PRG3 Protein (His Tag)

Product Specifications

Background

Proteoglycan 3, also known as Eosinophil major basic protein homolog, Prepro-major basic protein homolog, PRG3 and MBPH, contains one C-type lectin domain. Proteoglycans are a major component of the animal extracellular matrix. PRG3 localizes to the eosinophil secondary granule and is expressed in bone marrow, not detected in placenta. PRG3 has similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, PRG3 can stimulate neutrophil superoxide production and IL8 release, histamine and leukotriene C4 release from basophils.

Abbreviation

Proteoglycan 3; PRG3

Synonyms

Eosinophil Major Basic Protein Homolog; MBPH; PRG3; Prepro-MBPH; Prepro-Major Basic Protein Homolog; Proteoglycan 3

UniProt

Q9Y2Y8

Accession Number

AAI13412.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu18-Phe225

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.