Recombinant Human Proteinase 3/PRTN3 Protein (His Tag)
Product Specifications
Background
Proteinase-3 is a neutral serine proteinase that belongs to the peptidase S1 family and Elastase subfamily. It contains one peptidase S1 domain and it is expressed mainly in neutrophil granulocytes. The primary function of Proteinase-3 is thought to be degradation of extracellular proteins at sites of inflammation, but excessive or prolonged proteolytic activity may cause harmful effects in the body. It is the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
Abbreviation
Proteinase 3; PRTN3
Synonyms
AGP7; C-ANCA Antigen; Leukocyte Proteinase 3; MBN; Myeloblastin; NP-4; Neutrophil Proteinase 4; P29; PR-3; PR3; PRTN3; Wegener Autoantigen
UniProt
P24158
Accession Number
P24158
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ala26-Arg249
Field of Research
Signal Transduction
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
25.6 kDa
Observed Molecular Weight
34 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 10mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
Species
Human
Available Sizes
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