Recombinant Human Proteinase 3/PRTN3 Protein (His Tag)

Product Specifications

Background

Proteinase-3 is a neutral serine proteinase that belongs to the peptidase S1 family and Elastase subfamily. It contains one peptidase S1 domain and it is expressed mainly in neutrophil granulocytes. The primary function of Proteinase-3 is thought to be degradation of extracellular proteins at sites of inflammation, but excessive or prolonged proteolytic activity may cause harmful effects in the body. It is the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

Abbreviation

Proteinase 3; PRTN3

Synonyms

AGP7; C-ANCA Antigen; Leukocyte Proteinase 3; MBN; Myeloblastin; NP-4; Neutrophil Proteinase 4; P29; PR-3; PR3; PRTN3; Wegener Autoantigen

UniProt

P24158

Accession Number

P24158

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala26-Arg249

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

25.6 kDa

Observed Molecular Weight

34 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 10mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.

Species

Human

Available Sizes

Curated Selection

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