Recombinant Human PADI4 Protein (His Tag)
Product Specifications
Background
Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and a complex genetic component.
Abbreviation
PADI4
Synonyms
HL-60 PAD; PADI4; PADI5; PDI5; Peptidylarginine Deiminase IV; Protein-Arginine Deiminase Type-4; Protein-arginine Deiminase type IV
UniProt
Q9UM07
Accession Number
AAH25718.1
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Pro663
Field of Research
Signal Transduction; epigenetics and nuclear signal; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
76.2 kDa
Observed Molecular Weight
78 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 500mM NaCl, pH 7.5.
Species
Human
Available Sizes
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