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Recombinant Human PADI4 Protein (His Tag)

Product Specifications

Background

Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and a complex genetic component.

Abbreviation

PADI4

Synonyms

HL-60 PAD; PADI4; PADI5; PDI5; Peptidylarginine Deiminase IV; Protein-Arginine Deiminase Type-4; Protein-arginine Deiminase type IV

UniProt

Q9UM07

Accession Number

AAH25718.1

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Pro663

Field of Research

Signal Transduction; epigenetics and nuclear signal; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

76.2 kDa

Observed Molecular Weight

78 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 500mM NaCl, pH 7.5.

Species

Human

Available Sizes

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