Recombinant Human PKC epsilon/PKCE Protein (His Tag)
Product Specifications
Background
Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these domains: one AGC-kinase C-terminal domain; one C2 domain; one protein kinase domain and two phorbol-ester/DAG-type zinc fingers. Protein Kinase C Epsilon phosphorylate a variety of protein targets and has been identified to participate in diverse cellular signaling pathways. It has many different cellular functions; such as neuron channel activation; apoptosis; cardioprotection from ischemia; heat shock response; as well as insulin exocytosis. Protein Kinase C Epsilon also serves as the receptor for phorbol esters; a class of tumor promoters.
Abbreviation
PKC epsilon; PKCE
Synonyms
PKCE; PRKCE; Protein Kinase C Epsilon Type; nPKC-Epsilon
UniProt
Q02156
Accession Number
Q02156
Expression System
E.coli
Tag
C-His
Sequence
Gln580-Pro737
Field of Research
Signal Transduction; Cardiovascular; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
19.6 kDa
Observed Molecular Weight
20 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM DTT, pH 7.4.
Species
Human
Available Sizes
Curated Selection
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