Recombinant Human PDIA6 Protein (His Tag)
Product Specifications
Background
Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI) . PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. The PDIA6 expressed in platelets, its functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6 is part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1. PDIA6 also plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
Abbreviation
PDIA6
Synonyms
ER Protein 5; ERP5; ERp5; Endoplasmic Reticulum Protein 5; P5; PDIA6; Protein Disulfide Isomerase P5; Protein Disulfide-Isomerase A6; TXNDC7; Thioredoxin Domain-Containing Protein 7
UniProt
Q15084
Accession Number
Q15084
Expression System
HEK293 Cells
Tag
C-His
Sequence
Leu20-Leu440
Field of Research
Signal Transduction
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
47.2 kDa
Observed Molecular Weight
52 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
Species
Human
Available Sizes
Documents
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