Recombinant Human PSA/KLK3 Protein (aa 25-261, His Tag)
Product Specifications
Background
KLK3; also known as APS; is short for Prostate-specific antigen. It is a 261 aa. protein which belongs to the peptidase S1 family and Kallikrein subfamily. This protein has 5 isforms produced by alternative splicing. It is a secreted protein and can forms a heterodimer with SERPINA5 which can inhibit its activity. KLK3 is also strongly inhibited by Zn2+; 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins; which are avid zinc binders. KLK3 can hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Abbreviation
PSA; KLK3
Synonyms
APS; Gamma-Seminoprotein; Hk3; KLK2A1; Kallikrein-3; P-30 Antigen; PSA; Prostate-Specific Antigen; Semenogelase; Seminin
UniProt
P07288
Accession Number
P07288
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ile25-Pro261
Field of Research
Signal Transduction; Tags & Cell Markers; Neuroscience; Cancer; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
27.1 kDa
Observed Molecular Weight
35 kDa
Formulation
2
Species
Human
Available Sizes
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