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Recombinant Human PSA/KLK3 Protein (aa 25-261, His Tag)

Product Specifications

Background

KLK3; also known as APS; is short for Prostate-specific antigen. It is a 261 aa. protein which belongs to the peptidase S1 family and Kallikrein subfamily. This protein has 5 isforms produced by alternative splicing. It is a secreted protein and can forms a heterodimer with SERPINA5 which can inhibit its activity. KLK3 is also strongly inhibited by Zn2+; 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins; which are avid zinc binders. KLK3 can hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Abbreviation

PSA; KLK3

Synonyms

APS; Gamma-Seminoprotein; Hk3; KLK2A1; Kallikrein-3; P-30 Antigen; PSA; Prostate-Specific Antigen; Semenogelase; Seminin

UniProt

P07288

Accession Number

P07288

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ile25-Pro261

Field of Research

Signal Transduction; Tags & Cell Markers; Neuroscience; Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Product Datasheet

https://789.bio/ea/9kcldg

Product MSDS

https://789.bio/eb/vzbXfD

Calculated Molecular Weight

27.1 kDa

Observed Molecular Weight

35 kDa

Formulation

2

Species

Human

Available Sizes

Curated Selection

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