Recombinant Human HMBS Protein (His Tag)
Product Specifications
Background
Porphobilinogen Deaminase (HMBS) is a member of the HMBS family. PBGD is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. HMBS is involved in the production of heme, which is important for all of the body's organs, although it is most abundant in the blood, bone marrow, and liver. In addition, Heme is an essential component of iron-containing proteins called hemoproteins, including hemoglobin. Defects in PBGD are the cause of acute intermittent porphyria.
Abbreviation
HMBS
Synonyms
HMBS; Hydroxymethylbilane Synthase; PBG-D; PBGD; Porphobilinogen Deaminase; Pre-Uroporphyrinogen Synthase; UPS
UniProt
P08397
Accession Number
P08397
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ser2-His361
Field of Research
Signal Transduction; Cell biology; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
40.5 kDa
Observed Molecular Weight
47 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, 5% mannitol, 50% Glycerol, 0.1% Tween 80, pH7.4.
Species
Human
Available Sizes
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