Recombinant Human PSPH Protein (His Tag)
Product Specifications
Background
Phosphoserine phosphatase (PSP) is an enzyme that belongs to the serB family. PSPH catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Deficiency of this protein is thought to be linked to Williams syndrome. A disorder that results in pre- and postnatal growth retardation; moderate psychomotor retardation and facial features suggestive of Williams syndrome.
Abbreviation
PSPH
Synonyms
L-3-Phosphoserine Phosphatase; O-Phosphoserine Phosphohydrolase; PSP; PSPH; PSPase; Phosphoserine Phosphatase
UniProt
P78330
Accession Number
P78330
Expression System
E.coli
Tag
C-His
Sequence
Met 1-Glu225
Field of Research
Signal Transduction; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
26.1 kDa
Observed Molecular Weight
25-30 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 4M Urea, 5mM EDTA, pH 8.0.
Species
Human
Available Sizes
Documents
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