Recombinant Human Peroxiredoxin-3/PRDX3 Protein
Product Specifications
Background
Thioredoxin-Dependent Peroxide Reductase Mitochondrial (PRDX3) is an enzyme that belongs to the AhpC/TSA family. Human and mouse PRDX3 genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Human PRDX3 protein has an antioxidant function and is localized in the mitochondrion. PRDX3 is involved in redox regulation of the cell. PRDX3 protects radical-sensitive enzymes from oxidative damage by a radical-generating system. It acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
Abbreviation
Peroxiredoxin-3; PRDX3
Synonyms
AOP-1; AOP1; Antioxidant Protein 1; HBC189; PRDX3; Peroxiredoxin III; Peroxiredoxin-3; Protein MER5 homolog; Prx-III; Thioredoxin-Dependent Peroxide Reductase Mitochondrial
UniProt
P30048
Accession Number
P30048
Expression System
E.coli
Tag
None
Sequence
Pro63-Gln256
Field of Research
Signal Transduction; Cell biology; Cardiovascular; Neuroscience; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
21.6 kDa
Observed Molecular Weight
25 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, pH 8.0.
Species
Human
Available Sizes
Documents
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