Recombinant Human PPIH Protein (His Tag)
Product Specifications
Background
Peptidyl-Prolyl Cis-Trans Isomerase H (PPIH) belongs to the Cyclophilin-type PPIase family that accelerate the folding of proteins. PPIases can catalyze the cis-trans isomerization of Proline Imidic peptide bonds in oligopeptides. PPIH participates in pre-mRNA splicing. It is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. In addition, PPIH has PPIase activity and may play a role as a chaperone mediating the interactions between different proteins inside the spliceosome.
Abbreviation
PPIH
Synonyms
CYP20; CYPH; CypH; PPIH; PPIase H; Peptidyl-Prolyl Cis-Trans Isomerase H; Rotamase H; Small Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H; U-snRNP-Associated Cyclophilin SnuCyp-20; USA-CYP
UniProt
O43447
Accession Number
O43447
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Met 177
Field of Research
Signal Transduction; epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
21.4 kDa
Observed Molecular Weight
24 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Species
Human
Available Sizes
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