Recombinant Human FKBP4 Protein (His Tag)
Product Specifications
Background
FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
Abbreviation
FKBP4
Synonyms
51kDa FK506-binding protein;59kDa immunophilin; FK506-binding protein 4; FKBP4; FKBP59; HSP-binding immunophilin; Peptidyl-prolyl cis-trans isomerase FKBP4; Rotamase; immunophilin FKBP52
UniProt
Q02790
Accession Number
Q02790
Expression System
E.coli
Tag
C-His
Sequence
Met 1-Ala459
Field of Research
Signal Transduction; epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
52.8 kDa
Observed Molecular Weight
50-60 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Glycerol, pH 8.0.
Species
Human
Available Sizes
Curated Selection
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