Recombinant Human FKBP3/FKBP25 Protein (His Tag)
Product Specifications
Background
FKBP25 contains 1 PPIase FKBP-type domain; belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin; as well as histone deacetylases; the transcription factor YY1; casein kinase II; and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
Abbreviation
FKBP3; FKBP25
Synonyms
25 kDa FK506-binding protein;25 kDa FKBP; FK506-binding protein 3; FKBP-25; FKBP-3; FKBP25; Immunophilin FKBP25; PPIase FKBP3; Peptidyl-prolyl cis-trans isomerase FKBP3; Rapamycin-selective 25 kDa immunophilin; Rotamase
UniProt
Q00688
Accession Number
Q00688
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Asp224
Field of Research
Epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
27.3 kDa
Observed Molecular Weight
30 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 10% Glycerol, pH 8.0.
Species
Human
Available Sizes
Curated Selection
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