Recombinant Human Parvulin-14/PIN4 Protein (His Tag)
Product Specifications
Background
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4) is a peptidyl-prolyl cis/trans isomerase (PPIase) which interacts with NIMA and is vital for cell cycle regulation. PIN4 has 2 different isoforms: PAR14 and PAR17. Furthermore, PIN4 protein binds to double-stranded DNA under physiological salt conditions. PIN4 is involved as a ribosomal RNA processing factor in ribosome biogenesis. The PAR14 binds to tightly bent AT-rich stretches of double-stranded DNA, but PAR17 binds to double-stranded DNA.
Abbreviation
Parvulin-14; PIN4
Synonyms
PIN4; Parvulin-14; Parvulin-17; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Peptidyl-prolyl cis-trans isomerase Pin4; Peptidyl-prolyl cis/trans isomerase EPVH; Rotamase Pin4
UniProt
Q9Y237
Accession Number
Q9Y237-2
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Lys156
Field of Research
Epigenetics and Nuclear Signaling, Signal Transduction, Metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
18.8 kDa
Observed Molecular Weight
21 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.5.
Species
Human
Available Sizes
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