Recombinant Human PYM1/WIBG Protein (His Tag)
Product Specifications
Background
Partner of Y14 and Mago (WIBG) is a key regulator of the Exon Junction Complex (EJC) . EJC is a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs, is a positional landmarker for the intron exon structure of genes, and directs post-transcriptional processes in the cytoplasm, for instance mRNA export, nonsense-mediated mRNA decay or translation. WIBG is a cytoplasmic RNA-binding protein, it can be excluded from nucleus by Crm1. WIBG as a cooperateing partner of Mago-14, relates with Mago-14 by its N-terminal domain.
Abbreviation
PYM1; WIBG
Synonyms
PYM; Partner of Y14 and Mago; Protein Wibg Homolog; WIBG
UniProt
Q9BRP8
Accession Number
Q9BRP8
Expression System
E.coli
Tag
C-His
Sequence
Met 1-Leu204
Field of Research
Epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 80 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
23.7 kDa
Observed Molecular Weight
30 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 10% Glycerol, pH 8.0.
Species
Human
Available Sizes
Documents
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