Recombinant Human TNFSF4/OX40L Protein (His Tag)

Product Specifications

Background

Tumor necrosis factor ligand superfamily member 4 (TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells; T cells; dendritic cells and endothelial cells. OX40L binds to OX40 (CD134) ; a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proliferation and cytokine production. Additional; it has been found association with systemic lupus erythematosus; no association with occurrence of atherosclerosis.

Abbreviation

TNFSF4; OX40L

Synonyms

CD134L; CD252; GP34; Glycoprotein Gp34; OX-40; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFSF4; TXGP1; Tumor necrosis factor ligand superfamily member 4

UniProt

P23510

Accession Number

P23510

Expression System

HEK293 Cells

Tag

N-His

Sequence

Gln51-Leu183

Applications

BLI

Field of Research

Immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Loaded Biotinylated Human OX40L-His on AR2G Biosensor, can bind Human OX40-Fc with an affinity constant of 70.3 nM as determined in BLI assay.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.