Recombinant Human NME1/NDKA Protein (His Tag)
Product Specifications
Background
Nucleoside-Diphosphate Kinases (NDKs) are enzymes that catalyze the exchange of phosphate groups between different nucleoside diphosphates. NDKs Possesse nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3-5 exonuclease activities. NDKs involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression and required for neural development including neural patterning and cell fate determination. Prokaryotic NDK forms a functional homotetramer.There are two isoforms of NDK in humans: NDK-A and NDK-B. Both have very similar structure, and can combine in any proportion to form functional NDK hexamers.
Abbreviation
NME1; NDKA
Synonyms
AWD; GAAD; Granzyme A-Activated DNase; Metastasis Inhibition Factor nm23; NB; NBS; NDK A; NDKA; NDP Kinase A; NDPK-A; NDPKA; NM23; NM23-H1; NME1; Nucleoside Diphosphate Kinase A; Tumor Metastatic Process-Associated Protein; nm23-H1
UniProt
P15531
Accession Number
P15531
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Glu152
Field of Research
Cancer; epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
19.3 kDa
Observed Molecular Weight
21 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 10% Glycerol, pH 7.5.
Species
Human
Available Sizes
Documents
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