Recombinant Human N-Glycosylase/OGG1 Protein
Product Specifications
Background
Human N-Glycosylase/DNA Lyase (OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.
Abbreviation
N-Glycosylase; OGG1
Synonyms
8-Oxoguanine DNA Glycosylase; AP Lyase; DNA- (Apurinic or Apyrimidinic Site) Lyase; MMH; MUTM; N-Glycosylase/DNA Lyase; OGG1; OGH1
UniProt
O15527
Accession Number
AAH00657.1
Expression System
E.coli
Tag
None
Sequence
Met 1-Gly345
Field of Research
Cancer; epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
38.8 kDa
Observed Molecular Weight
38 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.5.
Species
Human
Available Sizes
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