Recombinant Human MPZL1 Protein (His Tag)

Product Specifications

Background

Myelin protein zero-like protein 1 (MPZL1) is encoded by the MPZL1 gene, which is a single-pass type I membrane protein. It is widely expressed with highest levels in heart, placenta, kidney and pancreas. As cell surface receptor, it involved in signal transduction processes. MPZL1 recruits PTPN11/SHP-2 to the cell membrane and subsequently activate/phosphorylate Src kinase at Tyr426, promoting phosphorylation of cortactin and migration of HCC cells. MPZL1also is a major receptor for concanavalin-A (ConA) and involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases.

Abbreviation

MPZL1

Synonyms

FLJ96614; Homo sapiens myelin protein zero-like 1 (MPZL1) ; Mrna; Myelin protein zero-like 1; cDNA; cDNA FLJ78597; highly similar to Homo sapiens myelin protein zero-like 1 (MPZL1) ; isoform CRA_b; mRNA; transcript variant 1

UniProt

O95297

Accession Number

O95297

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser36-Val162

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.