Recombinant Human MINPP1 Protein (His Tag)
Product Specifications
Background
Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) . MINPP1 may play a role in bone development (endochondral ossification) .
Abbreviation
MINPP1
Synonyms
2,3-BPG Phosphatase;2,3-Bisphosphoglycerate 3-Phosphatase; Inositol (1,3,4,5) -Tetrakisphosphate 3-Phosphatase; Ins (1,3,4,5) P (4) 3-Phosphatase; MINPP1; MIPP; Multiple Inositol Polyphosphate Phosphatase 1
UniProt
Q9UNW1
Accession Number
Q9UNW1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ser31-Leu487
Field of Research
Signal Transduction
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
53.1 kDa
Observed Molecular Weight
56 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.
Species
Human
Available Sizes
Documents
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